Question:medium
Which of the following causes increased renin on prolonged use?
Which of the following causes increased renin on prolonged use?
Show Hint
Blocking angiotensin II removes its negative feedback, so renin secretion rises.
Updated On: Jun 24, 2026
- Clonidine
- Enalapril
- Methyldopa
- Beta blocker
Show Solution
The Correct Option is B
Solution and Explanation
Step 1: The renin-angiotensin loop is held in check by angiotensin II, which feeds back to suppress further renin output from the kidney. Any drug that lowers angiotensin II will lift this suppression.
Step 2: Enalapril inhibits angiotensin converting enzyme, so less angiotensin I is turned into angiotensin II. With the inhibitory signal gone, the juxtaglomerular apparatus keeps releasing renin and plasma renin activity climbs over time.
Step 3: That points squarely to enalapril.
Step 4: The remaining choices push renin the other way. Clonidine and methyldopa act centrally as alpha-2 agonists and cut sympathetic outflow to the kidney, lowering renin. A beta blocker silences the beta-1 receptor that drives juxtaglomerular renin release, so it too reduces renin.
\[\boxed{\text{Enalapril}}\]
Step 2: Enalapril inhibits angiotensin converting enzyme, so less angiotensin I is turned into angiotensin II. With the inhibitory signal gone, the juxtaglomerular apparatus keeps releasing renin and plasma renin activity climbs over time.
Step 3: That points squarely to enalapril.
Step 4: The remaining choices push renin the other way. Clonidine and methyldopa act centrally as alpha-2 agonists and cut sympathetic outflow to the kidney, lowering renin. A beta blocker silences the beta-1 receptor that drives juxtaglomerular renin release, so it too reduces renin.
\[\boxed{\text{Enalapril}}\]
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