Question:medium
Which of the following causes hypokalemic metabolic alkalosis with hypertension?
Which of the following causes hypokalemic metabolic alkalosis with hypertension?
Show Hint
Which inherited tubular disorder raises blood pressure while lowering potassium via overactive ENaC?
Updated On: Jun 24, 2026
- Liddle syndrome
- Bartter syndrome
- Gitelman syndrome
- Renal tubular acidosis
Show Solution
The Correct Option is A
Solution and Explanation
Step 1: Several tubular disorders produce low potassium and alkalosis, so the deciding feature here is whether blood pressure is high.
Step 2: In Liddle syndrome the sodium channel ENaC is stuck on. The kidney hoards sodium and water, driving up blood pressure, while dumping potassium and acid, giving the hypokalemic alkalosis.
Step 3: Bartter and Gitelman share the electrolyte picture but keep blood pressure normal or low, and renal tubular acidosis moves the blood the other way into acidosis. Only Liddle pairs alkalosis with hypertension.
\[\boxed{\text{Liddle syndrome}}\]
Step 2: In Liddle syndrome the sodium channel ENaC is stuck on. The kidney hoards sodium and water, driving up blood pressure, while dumping potassium and acid, giving the hypokalemic alkalosis.
Step 3: Bartter and Gitelman share the electrolyte picture but keep blood pressure normal or low, and renal tubular acidosis moves the blood the other way into acidosis. Only Liddle pairs alkalosis with hypertension.
\[\boxed{\text{Liddle syndrome}}\]
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