Step 1: Sort the four drugs by how they are administered. Three of them must be injected, and only one can be swallowed.
Step 2: Rivaroxaban belongs to the oral direct factor Xa inhibitor family. Being a small, well absorbed molecule, it is taken as a tablet for DVT, pulmonary embolism, and atrial fibrillation, making it the answer.
Step 3: Alteplase is a clot dissolving enzyme that must run as an IV infusion since it is degraded within minutes. Argatroban, a thrombin blocker reserved for heparin induced thrombocytopenia, is also infused intravenously.
Step 4: Fondaparinux is delivered as a subcutaneous injection. Therefore the single orally effective option is Rivaroxaban.
\[\boxed{\text{Rivaroxaban}}\]