Question:easy
Which of the following agents is most commonly associated with carcinoma cervix?
Which of the following agents is most commonly associated with carcinoma cervix?
Show Hint
HPV 16 and 18 cause most cases, and 16 is the single most common.
Updated On: Jun 24, 2026
- HPV 16
- HPV 18
- HPV 33
- HPV 35
Show Solution
The Correct Option is A
Solution and Explanation
The question is about frequency, so think in terms of which type shows up most often in cervical cancer specimens.
Cervical carcinoma is fundamentally an HPV disease, specifically the high-risk oncogenic types. When you tally cases globally, two types dominate, type 16 and type 18, and between them they cover roughly seventy percent of all cervical cancers. The crucial detail is that type 16 alone accounts for about half of all cases, making it the clear single leader, while type 18 sits second and is more tied to the glandular adenocarcinoma subtype.
Mechanistically these high-risk types matter because their E6 and E7 proteins knock out the p53 and Rb tumor suppressor pathways, unleashing uncontrolled cell division. Types 33 and 35 belong to the high-risk family too, but they appear in only a small fraction of tumors, so neither comes close to type 16.
$HPV\ 16 + HPV\ 18 \approx 70\%,\ with\ 16\ leading$
\[\boxed{HPV\ 16}\]
Cervical carcinoma is fundamentally an HPV disease, specifically the high-risk oncogenic types. When you tally cases globally, two types dominate, type 16 and type 18, and between them they cover roughly seventy percent of all cervical cancers. The crucial detail is that type 16 alone accounts for about half of all cases, making it the clear single leader, while type 18 sits second and is more tied to the glandular adenocarcinoma subtype.
Mechanistically these high-risk types matter because their E6 and E7 proteins knock out the p53 and Rb tumor suppressor pathways, unleashing uncontrolled cell division. Types 33 and 35 belong to the high-risk family too, but they appear in only a small fraction of tumors, so neither comes close to type 16.
$HPV\ 16 + HPV\ 18 \approx 70\%,\ with\ 16\ leading$
\[\boxed{HPV\ 16}\]
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