Question

Which is the centrally acting alpha 2 agonist muscle relaxant

• A. Diazepam
• B. Bromocriptine
• C. Tizanidine
• D. Methocarbamol

Answer 1

The Correct Option is C

Step 1: The clue 'alpha-2 agonist' narrows the field to drugs sharing clonidine-like central action.

Step 2: Tizanidine fits exactly: it stimulates central alpha-2 receptors, cutting the release of excitatory amino acids in spinal interneurons and boosting inhibitory glycine signaling.

Step 3: The net result is reduced spasticity and fewer painful spasms while preserving voluntary strength, which is why it is favored in neurological spasticity.

Step 4: Diazepam (GABAergic), bromocriptine (dopaminergic), and methocarbamol (non-adrenergic central relaxant) do not match the alpha-2 mechanism.

\[\boxed{\text{Tizanidine}}\]