Question

Which is not true?

• A. vWD type 1 is mostly severe ds in children
• B. vWD type 3 mostly severe ds in children
• C. vWD type 2 is more related activity rather than levels
• D. vWD type 3 has severely low VWD

Hint:

Type 1 vWD is the commonest and mildest form — any statement calling it "severe" is the false one.

Answer 1

The Correct Option is A

Classify, then test each line against the classification. The cleanest way to answer a "which is NOT true" vWD question is to first fix the three subtypes in mind: Type 1 = partial quantitative deficiency and the mildest, commonest form; Type 2 = qualitative (dysfunctional vWF) so activity is hit harder than antigen level; Type 3 = complete quantitative deficiency, the most severe, with very low factor VIII too.

Now read each option:
• "Type 1 is mostly severe disease in children" - contradicts the rule that Type 1 is the mild form. This is the false statement.
• "Type 3 is mostly severe disease in children" - matches Type 3 being the severe, early-presenting form. True.
• "Type 2 relates more to activity than levels" - matches Type 2 being a functional defect, where ristocetin cofactor activity drops out of proportion to antigen. True.
• "Type 3 has severely low vWF" - matches the near-absent vWF of Type 3. True.

The single line that breaks the classification is the claim about Type 1 being severe. Therefore the statement that is NOT true is Option A.