Question:medium
Which is a short acting non-depolarizing neuromuscular blocker?
Which is a short acting non-depolarizing neuromuscular blocker?
Show Hint
It is hydrolysed by plasma cholinesterase, giving the briefest competitive block.
Updated On: Jun 24, 2026
- Rocuronium
- Suxamethonium
- Mivacurium
- Pancuronium
Show Solution
The Correct Option is C
Solution and Explanation
Step 1: First split the list into the two mechanistic classes. Depolarizers persistently stimulate the end plate, whereas non-depolarizers simply block acetylcholine binding. Suxamethonium is the depolarizer here and is removed at once.
Step 2: Among the remaining competitive agents, rank them by how long they last. Pancuronium is long acting, rocuronium is intermediate, leaving the search for the briefest one.
Step 3: Mivacurium fits: it is hydrolysed quickly by plasma (pseudo) cholinesterase, so its block wears off in about 15 to 20 minutes, the shortest of the competitive blockers.
Step 4: Thus the short acting non-depolarizing blocker is mivacurium.
\[\boxed{\text{Mivacurium}}\]
Step 2: Among the remaining competitive agents, rank them by how long they last. Pancuronium is long acting, rocuronium is intermediate, leaving the search for the briefest one.
Step 3: Mivacurium fits: it is hydrolysed quickly by plasma (pseudo) cholinesterase, so its block wears off in about 15 to 20 minutes, the shortest of the competitive blockers.
Step 4: Thus the short acting non-depolarizing blocker is mivacurium.
\[\boxed{\text{Mivacurium}}\]
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