Pancreatic juice and bicarbonate production is triggered by two primary hormones:
Cholecystokinin (CCK): Released by the small intestine when fats and proteins are detected, CCK signals the pancreas to secrete digestive enzymes within pancreatic juice.
Secretin: In response to acidic chyme entering the small intestine, secretin prompts the pancreas to produce bicarbonate-rich pancreatic juice, which neutralizes the acid. These hormones collectively facilitate efficient food breakdown in the digestive tract.