Step 1: Understanding the Question:
The question asks for the nitrogen oxide gas that significantly contributes to ozone layer depletion in the stratosphere. Step 2: Detailed Explanation:
1. Nitric oxide (NO) is released into the stratosphere by supersonic jets and through natural processes.
2. NO reacts rapidly with ozone ($O_3$) to form nitrogen dioxide and oxygen:
\[ NO(g) + O_3(g) \rightarrow NO_2(g) + O_2(g) \]
3. This catalytic cycle continuously destroys ozone molecules. Step 4: Final Answer:
NO is the primary gas among the options that causes ozone depletion.