Question

Which fluoroquinolone has the maximum oral bioavailability?

• A. Moxifloxacin
• B. Gatifloxacin
• C. Levofloxacin
• D. Ciprofloxacin

Hint:

Which quinolone is nearly 100 percent orally bioavailable.

Answer 1

The Correct Option is C

Step 1: The query is about which quinolone behaves almost the same whether given by mouth or by vein, which depends on oral bioavailability. Step 2: Norfloxacin is the poorly absorbed outlier of the group, used mainly for urinary and gut infections. Everything else absorbs well. Step 3: Levofloxacin stands out with roughly 100 percent oral bioavailability, allowing easy IV to oral switch. Ciprofloxacin lags at about 70 percent, and moxifloxacin and gatifloxacin, while high, are still beneath levofloxacin. Step 4: A practical caveat is that co-administered di- and trivalent cations bind these drugs and cut absorption, so dosing must be spaced. The answer therefore is levofloxacin. \[\boxed{\text{Levofloxacin}}\]