Question:medium

Which enzyme is primarily responsible for relieving supercoiling during DNA replication?

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Topoisomerases help prevent DNA from becoming tangled during replication by managing supercoiling.
Updated On: Jan 17, 2026
  • DNA helicase
  • DNA ligase
  • DNA polymerase
  • Topoisomerase
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The Correct Option is D

Solution and Explanation

Step 1: Define the function of topoisomerase.
Topoisomerase is an enzyme that alleviates DNA tension and supercoiling. It achieves this by temporarily cleaving DNA strands before rejoining them. This is essential for DNA replication.
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