Question:easy
Which drug is not included among DMARDs?
Which drug is not included among DMARDs?
Show Hint
One of these is a vinca alkaloid anticancer drug, not an antirheumatic agent.
Updated On: Jun 24, 2026
- Chloroquine
- Vincristine
- Azathioprine
- Leflunomide
Show Solution
The Correct Option is B
Solution and Explanation
Step 1: The question wants the odd drug out from a list where three are used to modify rheumatoid disease. So identify the one whose primary role lies elsewhere.
Step 2: Chloroquine (an antimalarial repurposed in arthritis), azathioprine (a purine antimetabolite immunosuppressant) and leflunomide (a pyrimidine synthesis inhibitor) are all standard antirheumatic agents that retard joint damage.
Step 3: Vincristine, by contrast, is a chemotherapy drug. It binds tubulin, halts mitosis at metaphase and is given for cancers such as acute lymphoblastic leukaemia and Hodgkin disease. It has no role in rheumatoid arthritis.
Step 4: Hence the drug excluded from the DMARD group is vincristine.
\[\boxed{\text{Vincristine}}\]
Step 2: Chloroquine (an antimalarial repurposed in arthritis), azathioprine (a purine antimetabolite immunosuppressant) and leflunomide (a pyrimidine synthesis inhibitor) are all standard antirheumatic agents that retard joint damage.
Step 3: Vincristine, by contrast, is a chemotherapy drug. It binds tubulin, halts mitosis at metaphase and is given for cancers such as acute lymphoblastic leukaemia and Hodgkin disease. It has no role in rheumatoid arthritis.
Step 4: Hence the drug excluded from the DMARD group is vincristine.
\[\boxed{\text{Vincristine}}\]
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