Question:medium
Which disease will show the following mode of inheritance?
Which disease will show the following mode of inheritance?
Show Hint
Only males affected, passed by carrier females, no father-to-son transmission = X-linked recessive — which listed disease is X-linked?
Updated On: Jun 22, 2026
- Wiskott (Wiskott-Aldrich syndrome)
- Wilson
- Prader willi
- Achondroplasia
Show Solution
The Correct Option is A
Solution and Explanation
Decode-the-pedigree approach.
First name the inheritance pattern from the diagram, then map it to a disease.
Pedigree clues present:
• Affected individuals are essentially all male (filled squares).
• Disease passes through unaffected carrier females (dotted circles).
• There is no male-to-male transmission (an affected father never passes it to his son).
This combination is diagnostic of X-linked recessive inheritance - affected males inherit the mutant X from carrier mothers, and fathers pass their X only to daughters (who become carriers).
Now test each option for X-linked recessive status:
• Wiskott-Aldrich → X-linked recessive (WAS gene) - MATCH.
• Wilson → autosomal recessive (ATP7B) - both sexes, sibling clustering; no.
• Prader-Willi → genomic imprinting / paternal 15q deletion; not X-linked; no.
• Achondroplasia → autosomal dominant (FGFR3); vertical, male-to-male possible; no.
Only Wiskott-Aldrich fits an X-linked recessive pedigree ($answer = Option\ A$, matching the key).
Memory aid: all-affected-male + carrier-female transmission + no father-to-son = X-linked recessive → here, Wiskott-Aldrich.
First name the inheritance pattern from the diagram, then map it to a disease.
Pedigree clues present:
• Affected individuals are essentially all male (filled squares).
• Disease passes through unaffected carrier females (dotted circles).
• There is no male-to-male transmission (an affected father never passes it to his son).
This combination is diagnostic of X-linked recessive inheritance - affected males inherit the mutant X from carrier mothers, and fathers pass their X only to daughters (who become carriers).
Now test each option for X-linked recessive status:
• Wiskott-Aldrich → X-linked recessive (WAS gene) - MATCH.
• Wilson → autosomal recessive (ATP7B) - both sexes, sibling clustering; no.
• Prader-Willi → genomic imprinting / paternal 15q deletion; not X-linked; no.
• Achondroplasia → autosomal dominant (FGFR3); vertical, male-to-male possible; no.
Only Wiskott-Aldrich fits an X-linked recessive pedigree ($answer = Option\ A$, matching the key).
Memory aid: all-affected-male + carrier-female transmission + no father-to-son = X-linked recessive → here, Wiskott-Aldrich.
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