Question:hard
Which condition is associated with congenital adrenal hypoplasia?
Which condition is associated with congenital adrenal hypoplasia?
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DAX-1 loss means deficient androgens in a genetic male.
Updated On: Jun 24, 2026
- Male pseudohermaphroditism
- Female pseudohermaphroditism
- True pseudohermaphroditism
- Sequential pseudohermaphroditism
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The Correct Option is A
Solution and Explanation
Step 1: Identify the genetic basis. Congenital adrenal hypoplasia in its X-linked form stems from loss or mutation of the $DAX-1$ gene, which devastates the adult adrenal cortex.
Step 2: Recall DAX1's reach. Beyond the adrenal, DAX1 governs proper development of the hypothalamic-pituitary-gonadal axis, so its failure impairs androgen production and signalling.
Step 3: Predict the genital outcome. A genetic male with deficient or ineffective androgen action becomes under-masculinised, the picture of male pseudohermaphroditism.
Step 4: Contrast with hyperplasia. Excess adrenal androgens in congenital adrenal hyperplasia virilise females (female pseudohermaphroditism), the opposite scenario, while true and sequential pseudohermaphroditism are not features of adrenal hypoplasia. Thus the associated condition is male pseudohermaphroditism.
\[\boxed{\text{Male pseudohermaphroditism}}\]
Step 2: Recall DAX1's reach. Beyond the adrenal, DAX1 governs proper development of the hypothalamic-pituitary-gonadal axis, so its failure impairs androgen production and signalling.
Step 3: Predict the genital outcome. A genetic male with deficient or ineffective androgen action becomes under-masculinised, the picture of male pseudohermaphroditism.
Step 4: Contrast with hyperplasia. Excess adrenal androgens in congenital adrenal hyperplasia virilise females (female pseudohermaphroditism), the opposite scenario, while true and sequential pseudohermaphroditism are not features of adrenal hypoplasia. Thus the associated condition is male pseudohermaphroditism.
\[\boxed{\text{Male pseudohermaphroditism}}\]
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