Question:medium
Which chromosome is responsible for the production of MIF (Mullerian inhibiting factor)?
Which chromosome is responsible for the production of MIF (Mullerian inhibiting factor)?
Show Hint
MIF follows testis formation, which is switched on by SRY on which chromosome?
Updated On: Jun 24, 2026
- Chromosome 16
- Chromosome 22
- X chromosome
- Y chromosome
Show Solution
The Correct Option is D
Solution and Explanation
Step 1: Trace where MIF comes from - it is anti-Mullerian hormone made by testicular Sertoli cells to regress the female ductal system in a male embryo. Step 2: A testis only forms when the $SRY$ gene, the testis-determining factor on the short arm of the $Y$ chromosome, switches on. Step 3: AMH production sits downstream of this SRY-driven testis formation, so the controlling chromosome is the Y chromosome. Step 4: Even though the AMH structural gene and receptor are autosomal, the question targets the chromosome responsible for triggering MIF production, which is the Y chromosome.\[\boxed{\text{Y chromosome}}\]
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