Question:medium
Which chromosome is responsible for the production of MIF (Mullerian Inhibiting Factor)?
Which chromosome is responsible for the production of MIF (Mullerian Inhibiting Factor)?
Show Hint
Follow the SRY testis-determining gene back to its chromosome.
Updated On: Jun 23, 2026
- Chromosome 16
- Chromosome 22
- X Chromosome
- Y chromosome
Show Solution
The Correct Option is D
Solution and Explanation
Step 1: The question is really asking which chromosome ultimately controls Mullerian regression. MIF/AMH causes regression of the Mullerian ducts in the male embryo.
Step 2: AMH is made by testicular Sertoli cells. Sertoli cells only exist because the gonad became a testis, and that fate is decided by the SRY master switch.
Step 3: SRY (the testis-determining factor) maps to the short arm of the $Y$ chromosome. Without a Y, there is no SRY, no testis, no Sertoli cells, and no MIF.
Step 4: Discard the other options: autosomes 16 and 22 host AMH structural and receptor loci but are not the determining chromosome the question wants, and the $X$ chromosome does not carry the male-determining trigger.
Step 5: So the chromosome responsible for MIF production is the Y chromosome.\[\boxed{\text{Y chromosome}}\]
Step 2: AMH is made by testicular Sertoli cells. Sertoli cells only exist because the gonad became a testis, and that fate is decided by the SRY master switch.
Step 3: SRY (the testis-determining factor) maps to the short arm of the $Y$ chromosome. Without a Y, there is no SRY, no testis, no Sertoli cells, and no MIF.
Step 4: Discard the other options: autosomes 16 and 22 host AMH structural and receptor loci but are not the determining chromosome the question wants, and the $X$ chromosome does not carry the male-determining trigger.
Step 5: So the chromosome responsible for MIF production is the Y chromosome.\[\boxed{\text{Y chromosome}}\]
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