Question:medium
Which best explains the LDH "Flipping effect"?
Which best explains the LDH "Flipping effect"?
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After an MI, cardiac LDH-1 rises above LDH-2 in serum.
Updated On: Jun 23, 2026
- LDH 1 > LDH 2
- LDH 2 > LDH 1
- LDH 2 > LDH 3
- LDH 3 > LDH 2
Show Solution
The Correct Option is A
Solution and Explanation
Step 1: Start from the baseline: in healthy serum LDH-2 sits above LDH-1, because LDH-1 is concentrated inside heart muscle and red cells rather than circulating freely. Step 2: A heart attack injures cardiac myocytes, which spill their LDH-1-rich contents into plasma. Step 3: This surge of LDH-1 pushes its serum level past LDH-2, inverting the usual order - that inversion is exactly what the term flipping effect names. Step 4: So the diagnostic flipped pattern of myocardial infarction is $\text{LDH-1} > \text{LDH-2}$, while the choices with LDH-2 on top simply restate the normal serum profile. \[\boxed{\text{LDH 1} > \text{LDH 2}}\]
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