Step 1: A chronic gastric ulcer is a defect in the stomach wall that persists because of ongoing inflammation, most often from H. pylori infection.
Step 2: H. pylori has a preference for the antral lining of the stomach, where it sets up chronic gastritis and weakens the mucosal defence. The region that bears the brunt is the pyloric antrum.
Step 3: Comparing the choices, the colon is part of the large bowel and is never a gastric ulcer site, while the antrum outranks the isolated lesser-curvature options as the classic location.
\[\boxed{\text{Pyloric antrum}}\]