Step 1: Think of VAP as a late-onset nosocomial pneumonia where Gram negative bacilli and resistant Gram positives predominate.
Step 2: Surveillance data put Pseudomonas aeruginosa at roughly 21 percent of isolates, narrowly the single most frequent cause, with Staphylococcus aureus close behind near 20 percent.
Step 3: The ESKAPE mnemonic (Enterococcus, Staphylococcus, Klebsiella, Acinetobacter, Pseudomonas, Enterobacter) captures the usual culprits. The community-pathogen Legionella, the lobar-pneumonia pneumococcus, and skin-flora coagulase negative staphylococcus are not the top VAP agents.
Step 4: As a single agent the answer is Pseudomonas.
\[\boxed{\text{Pseudomonas aeruginosa}}\]