Question:hard
What is the mechanism of action of teduglutide in short bowel syndrome?
What is the mechanism of action of teduglutide in short bowel syndrome?
Show Hint
It mimics the intestinotrophic peptide that drives bowel adaptation.
Updated On: Jun 23, 2026
- GLP-2 analog
- HT1a inhibitor
- GLP-1 analog
- C-peptide analog
Show Solution
The Correct Option is A
Solution and Explanation
Step 1: Short bowel syndrome leaves too little gut to absorb fluids and nutrients, so a drug that drives intestinal growth is therapeutically valuable.
Step 2: The natural peptide that stimulates this adaptive mucosal growth is GLP-2, and teduglutide is engineered to mimic it, so its mechanism is that of a GLP-2 analog.
Step 3: Clinically this translates into better fluid absorption and reduced reliance on intravenous parenteral nutrition, which is why it is FDA approved for adult short bowel syndrome.
Step 4: The other choices describe unrelated molecules - a GLP-1 analog for glycaemic control, a serotonin 5-HT1a target, and the insulin-derived C-peptide - so teduglutide is the GLP-2 analog.
\[\boxed{\text{GLP-2 analog}}\]
Step 2: The natural peptide that stimulates this adaptive mucosal growth is GLP-2, and teduglutide is engineered to mimic it, so its mechanism is that of a GLP-2 analog.
Step 3: Clinically this translates into better fluid absorption and reduced reliance on intravenous parenteral nutrition, which is why it is FDA approved for adult short bowel syndrome.
Step 4: The other choices describe unrelated molecules - a GLP-1 analog for glycaemic control, a serotonin 5-HT1a target, and the insulin-derived C-peptide - so teduglutide is the GLP-2 analog.
\[\boxed{\text{GLP-2 analog}}\]
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