Question:medium
What is the histological difference between Ulcerative colitis and Crohn's disease?
What is the histological difference between Ulcerative colitis and Crohn's disease?
Show Hint
Think of neutrophil collections inside the crypts that typify ulcerative colitis.
Updated On: Jun 23, 2026
- Diffuse distribution of pseudopolyps
- Mucosal edema
- Crypt abscess
- Lymphoid aggregates in the mucosa
Show Solution
The Correct Option is C
Solution and Explanation
Step 1: Approach this by recalling the depth and pattern of inflammation in each disease. UC is a mucosal disease that begins in the rectum and spreads proximally, while Crohn's disease is patchy and transmural. Step 2: On microscopy, UC shows neutrophils packed inside the intestinal crypts, forming crypt abscesses, together with crypt architectural distortion. Step 3: Crohn's disease is identified instead by non-caseating granulomas and full-thickness wall involvement, which are absent here as answer choices. Step 4: Matching the listed options, only the crypt abscess is a defining histological feature that points to UC over Crohn's disease, making option c correct. \[\boxed{\text{Crypt abscess}}\]
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