Step 1: Begin from the standard resting gas-exchange figures. Oxygen consumption is roughly 250 ml each minute, and carbon dioxide elimination is roughly 200 ml each minute.
Step 2: The question asks for the numerical gap between these two volumes. Subtract the smaller from the larger to get the answer.
\[250 \text{ ml/min} - 200 \text{ ml/min} = 50 \text{ ml/min}\]
Step 3: This gap exists because the respiratory exchange ratio is below one, around 0.8, on a typical mixed diet. Less CO2 is produced than O2 is consumed because fats and proteins yield less CO2 per molecule of O2 used than pure carbohydrate would.
Step 4: Hence the difference between O2 uptake and CO2 output is fifty millilitres per minute.
\[\boxed{50 \text{ ml/min}}\]