Question:easy
Warthin-Finkeldey cells are seen in which disease?
Warthin-Finkeldey cells are seen in which disease?
Show Hint
Grape-like multinucleated giant cells in lymph nodes point to a classic viral exanthem.
Updated On: Jun 24, 2026
- Measles
- Rubella
- Rabies
- Typhoid
Show Solution
The Correct Option is A
Solution and Explanation
Step 1: Recognise the cell as a named histologic clue. Warthin-Finkeldey cells are giant cells packed with many nuclei in a grape-like cluster, a buzzword pointing to a specific infection.
Step 2: That infection is measles. The virus enters through respiratory epithelium, seeds the reticuloendothelial system through viremia, and produces these multinucleated giant cells in hyperplastic lymph nodes during the early course. Therefore measles is the answer.
Step 3: The same cells can turn up in HIV infection and Kimura disease, but the classic textbook link tested here is measles.
Step 4: Pair the distractors with their own hallmarks: rabies with Negri bodies, typhoid with typhoid nodules, and rubella without this giant-cell finding, so none replaces measles.
\[\boxed{\text{Measles}}\]
Step 2: That infection is measles. The virus enters through respiratory epithelium, seeds the reticuloendothelial system through viremia, and produces these multinucleated giant cells in hyperplastic lymph nodes during the early course. Therefore measles is the answer.
Step 3: The same cells can turn up in HIV infection and Kimura disease, but the classic textbook link tested here is measles.
Step 4: Pair the distractors with their own hallmarks: rabies with Negri bodies, typhoid with typhoid nodules, and rubella without this giant-cell finding, so none replaces measles.
\[\boxed{\text{Measles}}\]
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