Question:easy
VIPoma is associated with which syndrome?
VIPoma is associated with which syndrome?
Show Hint
VIP excess gives watery diarrhoea, hypokalaemia, and achlorhydria (WDHA).
Updated On: Jun 24, 2026
- Zollinger Ellison
- Verner Morrison
- Carcinoid syndrome
- Cushing's syndrome
Show Solution
The Correct Option is B
Solution and Explanation
Step 1: The question links a specific functioning pancreatic islet-cell tumour to its eponymous syndrome. VIPoma releases vasoactive intestinal peptide, and the matching eponym is Verner-Morrison.
Step 2: Recall the secretory effect of VIP on the gut: it stimulates intestinal fluid secretion, producing a profuse watery diarrhoea that persists even during fasting. This loss of potassium-rich fluid leads to hypokalaemia, while gastric acid output falls, giving achlorhydria. The mnemonic WDHA (Watery Diarrhoea, Hypokalaemia, Achlorhydria) captures this, and pancreatic cholera is another name.
Step 3: Eliminate the wrong matches one by one. Gastrinoma maps to Zollinger-Ellison, not VIP. Serotonin and other amines map to carcinoid syndrome. Glucocorticoid excess maps to Cushing's syndrome. Only Verner-Morrison fits VIP.
Step 4: Most of these tumours are pancreatic in origin in adults, supporting the islet-cell tumour classification.
\[\boxed{\text{Verner Morrison}}\]
Step 2: Recall the secretory effect of VIP on the gut: it stimulates intestinal fluid secretion, producing a profuse watery diarrhoea that persists even during fasting. This loss of potassium-rich fluid leads to hypokalaemia, while gastric acid output falls, giving achlorhydria. The mnemonic WDHA (Watery Diarrhoea, Hypokalaemia, Achlorhydria) captures this, and pancreatic cholera is another name.
Step 3: Eliminate the wrong matches one by one. Gastrinoma maps to Zollinger-Ellison, not VIP. Serotonin and other amines map to carcinoid syndrome. Glucocorticoid excess maps to Cushing's syndrome. Only Verner-Morrison fits VIP.
Step 4: Most of these tumours are pancreatic in origin in adults, supporting the islet-cell tumour classification.
\[\boxed{\text{Verner Morrison}}\]
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