Question

Van Nuys prognostic index is not based on:

• A. Age
• B. Microcalcification
• C. Size
• D. ER status

Answer 1

The Correct Option is D

Step 1: Recall what the VNPI measures in DCIS - it pools four factors into a single score to guide whether wider excision or radiation is needed.
Step 2: Those four components are tumour size, surgical margin width, nuclear grade with necrosis status, and the age of the patient.
Step 3: Receptor status (ER, PR, HER2) is part of invasive cancer prognostication and treatment but is not folded into the Van Nuys score.
Step 4: Therefore the parameter the index is not based on is ER status.
\[\boxed{\text{ER status}}\]