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Using integration, find the area of the ellipse: \[ \frac{x^2}{16} + \frac{y^2}{4} = 1, \] included between the lines \(x = -2\) and \(x = 2\).

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To find the area of a region using integration, utilize symmetry to simplify calculations and make substitutions to handle square root expressions effectively.
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Solution and Explanation

The ellipse is described by the equation: \[ \frac{x^2}{16} + \frac{y^2}{4} = 1. \] To solve for \(y^2\), we rearrange: \[ \frac{y^2}{4} = 1 - \frac{x^2}{16}. \] This leads to: \[ y^2 = 4\left(1 - \frac{x^2}{16}\right) = 4 - \frac{x^2}{4}. \] Taking the square root gives: \[ y = \pm \sqrt{4 - \frac{x^2}{4}}. \]

Step 1: Leverage symmetry for simplification. The ellipse is symmetric about the \(x\)-axis. The area between \(x = -2\) and \(x = 2\) is twice the area above the \(x\)-axis: \[ \text{Area} = 2 \int_{-2}^{2} \sqrt{4 - \frac{x^2}{4}} \, dx. \] 

Step 2: Modify integration limits and perform integration. Due to the integrand's even nature (symmetry about the \(y\)-axis), the calculation can be further simplified: \[ \text{Area} = 4 \int_{0}^{2} \sqrt{4 - \frac{x^2}{4}} \, dx. \] 

Step 3: Employ substitution for simplification. 
Let \(u = 4 - \frac{x^2}{4}\). Then, \(du = -\frac{x}{2} \, dx\), which implies \(x \, dx = -2 \, du\). The limits of integration change as follows: when \(x = 0\), \(u = 4\); when \(x = 2\), \(u = 4 - \frac{2^2}{4} = 3\). 

The integral transforms into: \[ \int_{0}^{2} \sqrt{4 - \frac{x^2}{4}} \, dx = \int_{4}^{3} \sqrt{u} \cdot (-2) \, du. \] Simplification yields: \[ \int_{0}^{2} \sqrt{4 - \frac{x^2}{4}} \, dx = 2 \int_{3}^{4} \sqrt{u} \, du. \] 

Step 4: Evaluate the integral. The integral of \(\sqrt{u}\) is \(\frac{2}{3} u^{3/2}\). Evaluating this from \(u = 3\) to \(u = 4\): \[ \int_{3}^{4} \sqrt{u} \, du = \frac{2}{3} \left[4^{3/2} - 3^{3/2}\right]. \]
We simplify the terms: \(4^{3/2} = (2^2)^{3/2} = 2^3 = 8\) and \(3^{3/2} = \sqrt{3^3} = \sqrt{27}\). 
Therefore: \[ \int_{3}^{4} \sqrt{u} \, du = \frac{2}{3} \left[8 - \sqrt{27}\right]. \] 

Step 5: Determine the final area. Substitute this result back into the area formula: \[ \text{Area} = 4 \cdot 2 \cdot \frac{2}{3} \left[8 - \sqrt{27}\right] = \frac{16}{3} \left[8 - \sqrt{27}\right]. \] 

Final Answer: \[ \text{Area} = \frac{16}{3} \left[8 - \sqrt{27}\right]. \]

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