Question:medium

UDP-glucose is NOT used in?

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Which pathway runs straight from glucose-6-phosphate to make NADPH?
Updated On: Jun 24, 2026
  • Uronic acid pathway
  • Glycogen synthesis
  • Galactose metabolism
  • HMP shunt
Show Solution

The Correct Option is D

Solution and Explanation

Step 1: Think of UDP-glucose as a delivery van that carries activated glucose to several destinations. Identify which listed pathway it never visits.

Step 2: It delivers glucose for glycogen building, supplies the uronic acid cycle to form UDP-glucuronate, and participates in interconverting galactose. It is also used to attach sugars to proteins and lipids.

Step 3: The hexose monophosphate shunt branches off straight from glucose-6-phosphate and runs through 6-phosphogluconate to produce NADPH and pentose sugars. At no step does it require UDP-glucose.

Step 4: So the pathway that does not use UDP-glucose is the HMP shunt.

\[\boxed{\text{HMP shunt}}\]
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