Question

Two statements are given – one labelled Assertion (A) and the other labelled Reason (R). Select the correct answer from the codes given below:
Assertion (A): One of the first attempts to study the molecular basis of sickle cell anaemia was to compare the electrophoretic mobility of normal haemoglobin (Hb) and sickle cell haemoglobin (scHb).
Reason (R): Sickle cell haemoglobin (scHb) moved faster than normal haemoglobin (Hb) in electrophoresis.

• A. Both Assertion (A) and Reason (R) are true and the Reason (R) is the correct explanation of the Assertion (A).
• B. Both Assertion (A) and Reason (R) are true, but the Reason (R) is not the correct explanation of the Assertion (A).
• C. Assertion (A) is true, but Reason (R) is false.
• D. Assertion (A) is false, but Reason (R) is true.

Hint:

In electrophoresis, sickle cell haemoglobin moves slower than normal haemoglobin because of its altered charge.

Answer 1

The Correct Option is C

The molecular basis of sickle cell anaemia was elucidated by comparing the electrophoretic mobility of normal haemoglobin (Hb) and sickle cell haemoglobin (scHb). This analysis indicated that scHb exhibits slower migration than normal Hb, attributable to a charge difference.

• Assertion (A): True. This comparison was instrumental in the comprehension of sickle cell anaemia.
• Reason (R): False. Sickle cell haemoglobin migrates slower, not faster, than normal haemoglobin.

Consequently, the correct designation is (C).