Question:medium
True about Barrett's esophagus are all of the following except:
True about Barrett's esophagus are all of the following except:
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It is premalignant and raises cancer risk, but is saying it directly causes adenocarcinoma accurate?
Updated On: Jun 23, 2026
- Causes adenocarcinoma
- Patient is usually asymptomatic
- Histology of the lesion shows mucus secreting goblet cells
- Chronic gastroesophageal reflux is a predisposing factor
Show Solution
The Correct Option is A
Solution and Explanation
Step 1: The question asks which option is false, since it is framed as all true except one.
Step 2: Barrett's esophagus is a premalignant condition of the lower esophagus driven by long-standing acid reflux, in which squamous lining is replaced by columnar intestinal-type mucosa with goblet cells. It raises the risk of adenocarcinoma but is not the same as causing the cancer outright, so calling it a direct cause is the inaccurate statement.
Step 3: Reviewing the rest: the condition is generally silent so patients are usually asymptomatic, the biopsy classically reveals mucus-secreting goblet cells of intestinal metaplasia, and chronic GERD is the recognized predisposing factor. All three are correct.
Step 4: Hence the exception, the one statement that is not true, is that it causes adenocarcinoma.
\[\boxed{\text{Causes adenocarcinoma}}\]
Step 2: Barrett's esophagus is a premalignant condition of the lower esophagus driven by long-standing acid reflux, in which squamous lining is replaced by columnar intestinal-type mucosa with goblet cells. It raises the risk of adenocarcinoma but is not the same as causing the cancer outright, so calling it a direct cause is the inaccurate statement.
Step 3: Reviewing the rest: the condition is generally silent so patients are usually asymptomatic, the biopsy classically reveals mucus-secreting goblet cells of intestinal metaplasia, and chronic GERD is the recognized predisposing factor. All three are correct.
Step 4: Hence the exception, the one statement that is not true, is that it causes adenocarcinoma.
\[\boxed{\text{Causes adenocarcinoma}}\]
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