Question:medium
Translocation t(2;8)(p12;q24) is associated with:
Translocation t(2;8)(p12;q24) is associated with:
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8q24 is the MYC locus, so think which lymphoma is driven by MYC.
Updated On: Jun 24, 2026
- Chronic myeloid leukemia (CML)
- Acute myeloid leukemia (AML)
- T cell acute lymphoblastic leukemia (T-cell ALL)
- Burkitt lymphoma
Show Solution
The Correct Option is D
Solution and Explanation
The single most informative part of this question is the breakpoint at 8q24, because that band carries the MYC gene. Whenever a B-cell tumour shows a break at 8q24, the disease in play is Burkitt lymphoma, where MYC is forced into permanent overexpression.
Burkitt lymphoma comes with three related rearrangements. The usual one is t(8;14), joining MYC to the immunoglobulin heavy chain. There are also two light-chain variants: t(2;8), which lines MYC up with the kappa light-chain gene on chromosome 2, and t(8;22), which uses the lambda light-chain gene. The translocation given here, t(2;8)(p12;q24), is exactly the kappa variant.
Cross-check the wrong options. The Philadelphia chromosome t(9;22) belongs to CML. AML carries translocations like t(15;17) and t(8;21). T-cell ALL is driven by T-cell receptor gene rearrangements, not by 8q24. None matches the clue.
The answer therefore is Burkitt lymphoma.
\[\boxed{\text{Burkitt lymphoma (option D)}}\]
Burkitt lymphoma comes with three related rearrangements. The usual one is t(8;14), joining MYC to the immunoglobulin heavy chain. There are also two light-chain variants: t(2;8), which lines MYC up with the kappa light-chain gene on chromosome 2, and t(8;22), which uses the lambda light-chain gene. The translocation given here, t(2;8)(p12;q24), is exactly the kappa variant.
Cross-check the wrong options. The Philadelphia chromosome t(9;22) belongs to CML. AML carries translocations like t(15;17) and t(8;21). T-cell ALL is driven by T-cell receptor gene rearrangements, not by 8q24. None matches the clue.
The answer therefore is Burkitt lymphoma.
\[\boxed{\text{Burkitt lymphoma (option D)}}\]
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