Question

"Tram-line" intracranial calcifications seen on imaging are characteristic of which of the following conditions?

• A. Treacher Collins syndrome
• B. Sturge-Weber syndrome
• C. Tuberous sclerosis
• D. Neurofibromatosis type 1

Hint:

Tram-line or gyriform intracranial calcifications on imaging are a classic radiological sign of Sturge-Weber syndrome.

Answer 1

The Correct Option is B

The question asks about "tram-line" intracranial calcifications observed on imaging and their association with specific conditions. Let's examine the options and determine the correct answer.

1. Sturge-Weber syndrome: This is a neurological disorder known for its characteristic leptomeningeal angiomatosis, which often results in calcifications. These intracranial calcifications tend to appear on imaging as "tram-track" or "tram-line" patterns due to the calcification of parallel gyri neurons. This makes "tram-line" or "railroad track" appearance a hallmark feature of Sturge-Weber syndrome on scans.
2. Treacher Collins syndrome: This is a genetic disorder affecting craniofacial development. It primarily leads to facial abnormalities and does not typically present with "tram-line" intracranial calcifications.
3. Tuberous sclerosis: This is a genetic disorder characterized by the growth of benign tumors in multiple organs. While it can cause calcifications (e.g., subependymal nodules), they do not have the distinctive "tram-line" appearance.
4. Neurofibromatosis type 1: This condition involves the development of nerve tissue tumors and other symptoms like skin changes, but it does not usually present with "tram-line" intracranial calcifications.

Therefore, the correct answer is Sturge-Weber syndrome as it is the condition most consistently associated with "tram-line" intracranial calcifications.