Question:medium
Tolerance in opioids develops to all except?
Tolerance in opioids develops to all except?
Show Hint
Tolerance does not develop to two opioid effects: constipation and one pupil sign.
Updated On: Jun 24, 2026
- Miosis
- Analgesia
- Euphoria
- Nausea and vomiting
Show Solution
The Correct Option is A
Solution and Explanation
Chronic opioid exposure blunts most of the drug's actions, but the examiner is asking for the effect that escapes this adaptation. The reliable rule is that tolerance fails to develop to two effects, miosis and constipation, both mediated in ways that do not down-regulate with continued use; consequently pinpoint pupils stay a dependable clue in long-term users and in overdose. By contrast, the pain-relieving (analgesic), mood-elevating (euphoric), and gut-irritating (nausea and vomiting) actions all wane with repeated dosing, so those three options are all subject to tolerance. Mapping this onto the choices, analgesia, euphoria, and nausea/vomiting are eliminated because tolerance does occur to them, leaving miosis as the action to which tolerance does not develop and therefore the answer.\[\boxed{\text{Miosis}}\]
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