Question

The Wilson's disease is a rare inherited disorder due to accumulation in brain, liver, and other vital organs of:

• A. Iodine
• B. Copper
• C. Iron
• D. Calcium

Hint:

Wilson's disease involves copper buildup due to a defect in copper transport. Early diagnosis and treatment can prevent serious organ damage.

Answer 1

The Correct Option is B

Step 1: Understanding the Concept.
Wilson's disease belongs to a small group of inherited metal-storage disorders, and each one is tied to a failure in handling one specific metal.

Step 2: Key Approach.
Recall the gene and transport protein involved in Wilson's disease, then trace what metal it normally moves and what happens when that transport fails.

Step 3: Detailed Explanation.
The ATP7B gene codes for a protein that pumps copper out of liver cells into bile, which is the body's main route for removing excess copper.
A faulty ATP7B protein cannot move copper efficiently, so copper first piles up inside liver cells, damaging them, and once the liver's storage capacity is exceeded, copper leaks into the bloodstream and deposits in the brain, kidneys, and the cornea of the eye.
This is different from iron overload in hemochromatosis, and iodine and calcium disorders follow entirely separate pathways unrelated to the ATP7B transporter.

Step 4: Final Answer.
Wilson's disease results from the accumulation of copper in the brain, liver, and other organs.