Question

The Wilson's disease is a rare inherited disorder due to accumulation in brain, liver and other vital organs of:

• A. Iodine
• B. Copper
• C. Iron
• D. Calcium

Answer 1

The Correct Option is B

Step 1: Understanding the Question:
We need to name the metal whose faulty excretion from the body causes Wilson's disease.

Step 2: Key Concept:
Wilson's disease comes from a mutated ATP7B gene, which codes for a copper-transporting pump in liver cells, and without a working pump copper cannot be loaded into bile for removal from the body.

Step 3: Detailed Explanation:
Dietary copper is absorbed in the small intestine and carried to the liver, where it is normally either built into proteins such as ceruloplasmin or exported into bile. When the ATP7B pump fails, copper is trapped inside liver cells, and once the liver's storage capacity is used up, free copper spills into the blood and deposits in the brain, causing tremor and speech problems, in the cornea, causing Kayser-Fleischer rings, and in the kidneys. Neither iodine, iron, nor calcium follows this liver-overflow route.

Step 4: Final Answer:
Copper.