Step 1: Pattern approach
Pick which two positions hold vowels: there are $6$ ways, which is $^4C_2$.
Step 2: Fill each type
First vowel place: $5$ choices. Second vowel place: $4$ choices (no repeat), so $5\times 4 = ^5P_2$. Each consonant place: $21$ choices, so $21\times 21$.
Step 3: Combine
By the multiplication principle the number of words is $^4C_2\times{}^5P_2\times 21^2$, which is option (D).
Final Answer:
Option D.
\[ \boxed{\text{(D)}\ {}^4C_2\times {}^5P_2\times (21)^2} \]