Rather than matching the equation to a memorized standard form, we can derive the focus directly from the defining property of a parabola: every point on the curve is equidistant from the focus and from the directrix.
Since \( y^2 = 16x \) opens along the positive \( x \)-axis, let the focus be the point \( (h, 0) \) and the directrix be the vertical line \( x = -h \), for some positive value \( h \). For any point \( (x, y) \) on the parabola, the distance to the focus must equal the distance to the directrix:
\[ \sqrt{(x - h)^2 + y^2} = x + h \]Squaring both sides:
\[ (x - h)^2 + y^2 = (x + h)^2 \]\[ x^2 - 2hx + h^2 + y^2 = x^2 + 2hx + h^2 \]\[ y^2 = 4hx \]Comparing this derived relation \( y^2 = 4hx \) with the given equation \( y^2 = 16x \), we get \( 4h = 16 \), so \( h = 4 \).
We can verify this with an actual point on the curve. Taking \( x = 4 \), we get \( y^2 = 16(4) = 64 \), so \( y = 8 \), giving the point \( (4, 8) \). The distance from \( (4, 8) \) to the focus \( (4, 0) \) is \( \sqrt{(4-4)^2 + 8^2} = 8 \), and the distance from \( (4, 8) \) to the directrix \( x = -4 \) is \( 4 - (-4) = 8 \). Both distances match, confirming the focus.
Therefore, the correct answer is \( (4, 0) \).