Question:hard
The chromophobe variant of renal cell carcinoma is associated with:
The chromophobe variant of renal cell carcinoma is associated with:
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Chromophobe loses chromosomes; think monosomy, not trisomy.
Updated On: Jun 24, 2026
- VHL gene mutations
- Trisomy of 7 and 17 (+7, +17)
- 3p deletions (3p-)
- Monosomy of 1 and Y (-1, -Y)
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The Correct Option is D
Solution and Explanation
This is a matching exercise between renal cell carcinoma subtypes and their chromosome fingerprints, so build the map and then read off the answer. The clear cell type, by far the most common, owes its biology to the VHL gene that sits on the short arm of chromosome 3; accordingly it carries VHL mutations and loss of 3p material. The papillary type is the one defined by extra chromosomes, classically gains of chromosomes 7 and 17 along with loss of the Y chromosome. The chromophobe type behaves differently again: instead of gaining material it loses whole chromosomes, ending up hypodiploid, with the textbook losses being monosomy of chromosome 1 and of the Y chromosome among several others. Lining the options against this map, VHL mutations and 3p deletions are clear cell features, and trisomy 7 and 17 is the papillary signature, so both are wrong for chromophobe. The fingerprint that belongs to chromophobe carcinoma is the monosomy of chromosomes 1 and Y.
\[\boxed{\text{Monosomy of 1 and Y}}\]
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