Question

The chelating ligand used to remove excess of copper and iron in chelate therapy is

• A. D-Penicillamine
• B. Oxalate ion
• C. EDTA
• D. Ethylene diamine
• E. Dimethyl glyoxime

Hint:

Higher denticity ⇒ stronger chelation ⇒ EDTA (hexadentate) is most powerful.

Answer 1

The Correct Option is C

Understanding the Concept: Chelation therapy uses ligands that can form multiple bonds (multidentate ligands) with metal ions to remove them from the body.

Step 1: Identify strongest chelating ligand EDTA is a hexadentate ligand → binds metal ions strongly and forms very stable complexes.

Step 2: Application EDTA is widely used in:
• Lead poisoning
• Excess Cu and Fe removal

Step 3: Reject others
• D-Penicillamine: specific for Cu (Wilson disease)
• Oxalate: weak ligand
• Ethylenediamine: bidentate only
• Dimethylglyoxime: specific for Ni \[ \boxed{\text{EDTA is correct}} \]