Question

The adult dose of Nimesulide is 100mg. What is the dose for a child weighing 12Lbs as per Clark’s formula?

• A. 8mg
• B. 16mg
• C. 10mg
• D. 50mg

Hint:

When calculating pediatric doses, Clark’s formula helps to adjust the adult dose according to the child’s weight, ensuring safe and appropriate medication.

Answer 1

The Correct Option is A

Step 1: Convert the child's weight to kilograms: \( 12 \, \text{lb} \times 0.4536 = 5.44 \, \text{kg} \).
Step 2: Clark's rule can also be applied using the average adult body weight of 70 kg instead of 150 lb: \( \text{Child's dose} = \frac{\text{weight (kg)}}{70} \times \text{adult dose} \).
Step 3: Substitute the values: \( \frac{5.44}{70} \times 100 = 7.77 \, \text{mg} \), which rounds to the nearest standard option.
\[ \boxed{8 \, \text{mg}} \]

Answer 2

Another way to confirm the answer is to set up Clark's rule as an equation and solve for the unknown dose directly, then compare with each option.

1. 8mg: Setting up the equation \( \frac{x}{100} = \frac{12}{150} \) and cross-multiplying gives \( 150x = 1200 \), so \( x = 8 \). This matches exactly, confirming this option.
2. 16mg: Substituting \( x = 16 \) gives \( 150 \times 16 = 2400 \), but \( 100 \times 12 = 1200 \), and \( 2400 \neq 1200 \), so this does not satisfy the equation.
3. 10mg: Substituting \( x = 10 \) gives \( 150 \times 10 = 1500 \), which does not equal \( 1200 \), so this option is also inconsistent.
4. 50mg: Substituting \( x = 50 \) gives \( 150 \times 50 = 7500 \), far from \( 1200 \), so this option is clearly incorrect.

Only \( x = 8 \) satisfies the cross-multiplied equation exactly.

Therefore, the correct answer is 8mg.