Question:easy
Tadalafil should not be given together with:
Tadalafil should not be given together with:
Show Hint
Adding another vasodilator (like nitrates) to a PDE-5 inhibitor crashes blood pressure.
Updated On: Jun 24, 2026
- Vasodilators
- Antibiotics
- Vasoconstrictors
- Valproate
Show Solution
The Correct Option is A
Solution and Explanation
Step 1: Tadalafil blocks phosphodiesterase-5, sustaining cGMP-mediated smooth-muscle relaxation and vasodilation.
Step 2: If another vasodilating drug (classically a nitrate) is added, the two effects stack, producing a steep and potentially dangerous drop in blood pressure.
Step 3: For that reason vasodilators are contraindicated alongside tadalafil.
Step 4: The other options - antibiotics, vasoconstrictors, and valproate - lack this additive hypotensive risk, so they are not the answer.
\[\boxed{\text{Vasodilators}}\]
Step 2: If another vasodilating drug (classically a nitrate) is added, the two effects stack, producing a steep and potentially dangerous drop in blood pressure.
Step 3: For that reason vasodilators are contraindicated alongside tadalafil.
Step 4: The other options - antibiotics, vasoconstrictors, and valproate - lack this additive hypotensive risk, so they are not the answer.
\[\boxed{\text{Vasodilators}}\]
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