Question:medium
Sweaty feet odour in urine is seen in?
Sweaty feet odour in urine is seen in?
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Sweaty feet odour points to isovaleric acidemia; mousy is PKU, maple syrup is MSUD.
Updated On: Jun 24, 2026
- Phenylketonuria
- Maple syrup urine disease
- Isovaleric acidemia
- Alkaptonuria
Show Solution
The Correct Option is C
Solution and Explanation
Step 1: This is an odour-to-disease matching question among four metabolic disorders, so recall each signature smell.
Step 2: The sweaty feet or cheesy aroma is the textbook clue for isovaleric acidemia, where a block in leucine breakdown lets isovaleric acid build up. Glutaric aciduria type II shares this scent.
Step 3: Phenylketonuria smells mousy or musty from phenylacetic acid, and maple syrup urine disease smells of burnt sugar or maple syrup from branched chain keto acids. Neither fits sweaty feet.
Step 4: Alkaptonuria does not give a strong fresh smell; instead the urine turns black on standing as homogentisic acid oxidises. The only match for sweaty feet is isovaleric acidemia.
\[\boxed{\text{Isovaleric acidemia}}\]
Step 2: The sweaty feet or cheesy aroma is the textbook clue for isovaleric acidemia, where a block in leucine breakdown lets isovaleric acid build up. Glutaric aciduria type II shares this scent.
Step 3: Phenylketonuria smells mousy or musty from phenylacetic acid, and maple syrup urine disease smells of burnt sugar or maple syrup from branched chain keto acids. Neither fits sweaty feet.
Step 4: Alkaptonuria does not give a strong fresh smell; instead the urine turns black on standing as homogentisic acid oxidises. The only match for sweaty feet is isovaleric acidemia.
\[\boxed{\text{Isovaleric acidemia}}\]
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