Question:easy
Streptokinase and urokinase are contraindicated in:
Streptokinase and urokinase are contraindicated in:
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Clot busters risk fatal bleeding; which option sits inside the skull?
Updated On: Jun 24, 2026
- Intracranial malignancy
- Pulmonary embolism
- Arteriovenous fistula
- Thrombophlebitis
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The Correct Option is A
Solution and Explanation
Streptokinase and urokinase break down clots, so the real danger with them is bleeding. The question asks where giving them would be unsafe.
The most feared complication of any thrombolytic is bleeding into the brain. Because of this, lesions inside the skull are absolute reasons to avoid these drugs. An intracranial malignancy is exactly such a lesion, with fragile tumor vessels that can bleed massively once the clotting system is disabled. That makes intracranial malignancy the contraindication and the correct answer.
The other options do not fit. Pulmonary embolism is one of the situations where these drugs are actually used to dissolve the clot, so it is an indication rather than a contraindication. An arteriovenous fistula is not a standard absolute bar to these agents. Thrombophlebitis is a clotting condition, the kind of problem thrombolytics are meant to address, so it is not a reason to withhold them.
So the setting where these drugs are contraindicated is the brain tumor.
$$\boxed{\text{Intracranial malignancy}}$$
The most feared complication of any thrombolytic is bleeding into the brain. Because of this, lesions inside the skull are absolute reasons to avoid these drugs. An intracranial malignancy is exactly such a lesion, with fragile tumor vessels that can bleed massively once the clotting system is disabled. That makes intracranial malignancy the contraindication and the correct answer.
The other options do not fit. Pulmonary embolism is one of the situations where these drugs are actually used to dissolve the clot, so it is an indication rather than a contraindication. An arteriovenous fistula is not a standard absolute bar to these agents. Thrombophlebitis is a clotting condition, the kind of problem thrombolytics are meant to address, so it is not a reason to withhold them.
So the setting where these drugs are contraindicated is the brain tumor.
$$\boxed{\text{Intracranial malignancy}}$$
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