Question

Space of Disse is in:

• A. Spleen
• B. Lymph node
• C. Liver
• D. Bone

Hint:

It is the perisinusoidal space between hepatocyte and sinusoid.

Answer 1

The Correct Option is C

Step 1: Locate the anatomy. The space of Disse is a thin perisinusoidal channel sitting between the plates of liver cells and the endothelium lining the hepatic sinusoids. Step 2: Its function is exchange - it is filled with plasma that has filtered out of the leaky sinusoidal endothelium, and the brush border of hepatocyte microvilli reaches into it to absorb proteins and nutrients. Step 3: Stellate fat-storing cells also lie within this space and are key in hepatic fibrosis. Step 4: None of the other listed organs - spleen, lymph node or bone - has hepatocytes or hepatic sinusoids, so the space of Disse can only be the liver. \[\boxed{\text{Liver}}\]