Question

Shock organ in anaphylaxis is

• A. Liver
• B. Lung
• C. Kidney
• D. Spleen

Hint:

In guinea pigs, the lungs are also the primary shock organ, making them a common model for anaphylaxis.

Answer 1

The Correct Option is B

Step 1: State the concept.
The shock organ is the organ most severely affected during an anaphylactic (severe allergic) reaction. It varies between species, and the question asks about humans.
Step 2: Recall the mechanism of anaphylaxis.
In anaphylaxis, mast cells release histamine and other mediators. In humans these mediators cause intense bronchoconstriction and airway swelling, making breathing the critical problem.
Step 3: Identify the human shock organ.
Because the respiratory tract bears the brunt of this reaction, the lung is regarded as the shock organ in human systemic anaphylaxis.
Step 4: Eliminate liver and kidney.
Option 1 (liver) and option 3 (kidney) are not the primary targets of the mediators in human anaphylaxis, so both are rejected.
Step 5: Eliminate spleen.
Option 4 (spleen) is the shock organ in some animals like rabbits, but not in humans, so it is discarded for this question.
Step 6: Conclude.
The shock organ in human anaphylaxis is the lung, which is option 2.
\[ \boxed{\text{Option 2: Lung}} \]