Question:medium
Sacubitril is a:
Sacubitril is a:
Show Hint
It is the neprilysin-blocking half of the valsartan combination used in heart failure.
Updated On: Jun 24, 2026
- ACE inhibitor
- Neutral endopeptidase inhibitor
- Calcium channel inhibitor
- Beta adrenergic blocker
Show Solution
The Correct Option is B
Solution and Explanation
Step 1: The combination drug sacubitril/valsartan is an ARNI, and the angiotensin receptor part is valsartan, so sacubitril must supply the other mechanism.
Step 2: Sacubitril is activated to its metabolite, which blocks neprilysin (the neutral endopeptidase that degrades natriuretic peptides, bradykinin, and adrenomedullin).
Step 3: Blocking this enzyme keeps beneficial vasodilatory and natriuretic peptides around longer, helping unload the failing heart.
Step 4: Therefore sacubitril is correctly classed as a neutral endopeptidase inhibitor, not an ACE inhibitor or any of the other classes.
\[\boxed{\text{Neutral endopeptidase (neprilysin) inhibitor}}\]
Step 2: Sacubitril is activated to its metabolite, which blocks neprilysin (the neutral endopeptidase that degrades natriuretic peptides, bradykinin, and adrenomedullin).
Step 3: Blocking this enzyme keeps beneficial vasodilatory and natriuretic peptides around longer, helping unload the failing heart.
Step 4: Therefore sacubitril is correctly classed as a neutral endopeptidase inhibitor, not an ACE inhibitor or any of the other classes.
\[\boxed{\text{Neutral endopeptidase (neprilysin) inhibitor}}\]
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