Question

Russell bodies are found in -

• A. Multiple myeloma
• B. Gonadal tumor
• C. Parkinsonism
• D. Intracranial neoplasms

Hint:

These eosinophilic immunoglobulin inclusions belong to plasma cells.

Answer 1

The Correct Option is A

Step 1: Trace the inclusion to its parent cell. A Russell body is a globule of immunoglobulin trapped within the cytoplasm of a plasma cell. So whichever option is a plasma cell disorder is the answer.

Step 2: Scan the choices for a plasma cell condition. Multiple myeloma is precisely that, a clonal proliferation of plasma cells overproducing immunoglobulin. The protein backs up inside the cells and condenses into Russell bodies.

Step 3: Note the companion findings of the same disease to reinforce the link. Mott cells with grape-like blue droplets, flame cells with red cytoplasm, and Dutcher bodies inside the nucleus all appear in myeloma plasma cells, confirming the family of immunoglobulin inclusions.

Step 4: Dismiss the non-plasma-cell options. Gonadal tumours, Parkinson disease (Lewy bodies) and intracranial neoplasms produce neither plasma cells nor Russell bodies. The match is multiple myeloma.

\[\boxed{\text{Multiple myeloma}}\]