Question:hard
Regarding gout, which of the following is the underlying metabolic basis?
Regarding gout, which of the following is the underlying metabolic basis?
Show Hint
Look for the root enzymatic defect, not a complication.
Updated On: Jun 24, 2026
- Uric acid nephrolithiasis
- Deficiency of the enzyme involved in purine metabolism
- Increase in serum urate concentration
- Renal disease involving the interstitial tissues
Show Solution
The Correct Option is B
Solution and Explanation
Step 1: The question targets the fundamental metabolic defect behind gout rather than its clinical complications.
Step 2: Gout arises when purine breakdown is faulty because of a missing enzyme in the purine pathway, so purines are not fully processed for renal excretion and uric acid builds up.
Step 3: This enzymatic shortfall raises serum urate, and urate crystals then precipitate in joints to cause the painful attacks.
Step 4: Stone formation, raised serum urate, and interstitial nephropathy are downstream effects, while the enzyme deficiency in purine metabolism is the core cause per this recall key.
\[\boxed{\text{Deficiency of enzyme in purine metabolism}}\]
Step 2: Gout arises when purine breakdown is faulty because of a missing enzyme in the purine pathway, so purines are not fully processed for renal excretion and uric acid builds up.
Step 3: This enzymatic shortfall raises serum urate, and urate crystals then precipitate in joints to cause the painful attacks.
Step 4: Stone formation, raised serum urate, and interstitial nephropathy are downstream effects, while the enzyme deficiency in purine metabolism is the core cause per this recall key.
\[\boxed{\text{Deficiency of enzyme in purine metabolism}}\]
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