Question:easy
Reed-Sternberg cells are found in which condition?
Reed-Sternberg cells are found in which condition?
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Owl's eye RS cells (CD30+, CD15+) are pathognomonic of Hodgkin's lymphoma.
Updated On: Jun 23, 2026
- Hodgkin's disease
- Sickle cell anaemia
- Thalassemia
- CML
Show Solution
The Correct Option is A
Solution and Explanation
Step 1: Recall the single defining cell asked about. The Reed-Sternberg cell - a giant cell with an "owl's eye" bilobed or multinucleated nucleus and big eosinophilic nucleoli - is the diagnostic cell of Hodgkin's lymphoma.
Step 2: Its presence is essentially required to diagnose Hodgkin's disease; conversely its absence carries a high negative predictive value.
Step 3: Markers $CD30^{+}$ and $CD15^{+}$ with $CD20^{-}$ and $CD45^{-}$ confirm the RS lineage from crippled germinal-center B cells.
Step 4: Sickle cell anaemia, thalassemia and chronic myeloid leukemia (CML) are unrelated hematologic disorders with distinct morphology (sickled cells, target cells, leukocytosis with basophilia), none of which contain RS cells.
\[\boxed{\text{Hodgkin's disease}}\]
Step 2: Its presence is essentially required to diagnose Hodgkin's disease; conversely its absence carries a high negative predictive value.
Step 3: Markers $CD30^{+}$ and $CD15^{+}$ with $CD20^{-}$ and $CD45^{-}$ confirm the RS lineage from crippled germinal-center B cells.
Step 4: Sickle cell anaemia, thalassemia and chronic myeloid leukemia (CML) are unrelated hematologic disorders with distinct morphology (sickled cells, target cells, leukocytosis with basophilia), none of which contain RS cells.
\[\boxed{\text{Hodgkin's disease}}\]
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