Question

Reed sternberg cells are found in

• A. Hodgkin's disease
• B. Sickle cell anaemia
• C. Thalassemia
• D. CML

Answer 1

The Correct Option is A

Step 1: Identify the disease by its signature cell. The Reed-Sternberg cell, with its owl-eye double nucleus, defines one specific lymphoma.

Step 2: These B-cell-derived giant cells sit against a background of reactive lymphocytes and carry the immunophenotype CD30+ and CD15+ while being CD20- and CD45-, which is characteristic of Hodgkin lymphoma.

Step 3: Finding these cells is essential to confirm Hodgkin lymphoma; not finding them strongly argues against the diagnosis.

Step 4: The remaining options are hemoglobinopathies (sickle cell, thalassemia) and a myeloproliferative disorder (CML), none of which feature Reed-Sternberg cells. Hence the answer is Hodgkin's disease.

\[\boxed{\text{Hodgkin's disease}}\]