Question:medium
Plasmapheresis is used in all of the following except:
Plasmapheresis is used in all of the following except:
Show Hint
Plasmapheresis clears antibodies; a cholinergic crisis is a drug overdose, so it does not apply.
Updated On: Jun 24, 2026
- Myasthenic crisis
- Cholinergic crisis
- Guillain-Barre syndrome
- Polymyositis
Show Solution
The Correct Option is B
Solution and Explanation
Frame the rule first. Plasmapheresis works by washing harmful antibodies and immune complexes out of the blood, so it is reserved for antibody driven autoimmune disease. The exception will be the condition that has nothing to do with antibodies.
Myasthenic crisis is antibody mediated, with anti acetylcholine receptor antibodies causing dangerous weakness; clearing them helps fast, so option A qualifies.
Guillain-Barre syndrome is an autoimmune attack on peripheral nerves, and plasma exchange is a first line treatment that speeds recovery, so option C qualifies.
Polymyositis is an autoimmune muscle inflammation, and plasmapheresis may be tried when standard immunosuppression fails, so option D qualifies.
Cholinergic crisis is different in kind. It comes from too much anticholinesterase medication flooding the junction with acetylcholine. The fix is to withdraw the drug, give atropine, and support breathing. There is no antibody to remove, so plasmapheresis has no role. That makes option B the exception.
\[\boxed{\text{Cholinergic crisis}}\]
Myasthenic crisis is antibody mediated, with anti acetylcholine receptor antibodies causing dangerous weakness; clearing them helps fast, so option A qualifies.
Guillain-Barre syndrome is an autoimmune attack on peripheral nerves, and plasma exchange is a first line treatment that speeds recovery, so option C qualifies.
Polymyositis is an autoimmune muscle inflammation, and plasmapheresis may be tried when standard immunosuppression fails, so option D qualifies.
Cholinergic crisis is different in kind. It comes from too much anticholinesterase medication flooding the junction with acetylcholine. The fix is to withdraw the drug, give atropine, and support breathing. There is no antibody to remove, so plasmapheresis has no role. That makes option B the exception.
\[\boxed{\text{Cholinergic crisis}}\]
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